Sunish Mohanan
Seminars
Thursday 23rd October 2025
Spatial Multi-Omics of Crohn’s Disease: Advancing Pathobiology & Target Discovery in Biopharma
9:00 am
- Highlighting the application of cutting-edge spatial omics technologies – including spatial transcriptomics, single-nucleus RNA sequencing, and high-order multiplexed protein imaging – to study the complex pathobiology of Crohn’s disease using FFPE tissue
- Integrating spatial and single-cell data with histological annotation, we reveal distinct epithelial states, immune-stromal interactions, and ulcer-associated transcriptional programs that inform therapeutic hypothesis generation
- Harnessing this multi-omics approach enables high-resolution, spatially contextualized insights directly from archived clinical samples, offering a powerful platform for target discovery and translational research in chronic inflammatory diseases
Thursday 23rd October 2025
Panel Discussion: Leveraging Spatial Biology to Unlock Novel Insights into Complex Disease for Enhanced Therapeutic & Biomarker Development
11:30 am
- What are some of the most promising ways spatial biology is helping us better understand complex disease mechanisms that traditional approaches may miss?
- How can we translate novel spatial insights into robust, clinically relevant biomarkers and therapeutic targets that hold up across different patient populations?
- What practical steps are needed to integrate spatial biology more effectively into discovery and development pipelines?
